Production of Fibrinolytic Enzyme by Streptomyces Rimosus at Conditions of Nitrogen Limitation

The kinetic of the enzyme production of Streptomyces rimosus, a producer of exoproteases was investigated in conditions of nitrogen limitation.The maxima of fibrinolytic and caseinolytic activities by Streptomyces rimosus were reached at 84 h, respectively 96 h. Values of activities were increased 5-fold with those on initial medium. The ultrastructure changes were followed. In the earlier hours an aggregation of ribosomes in cells was established. Large membranes and numerous electron-transparent structures were found. The obtained results indicated close connection between cell status of the producer, its enzyme productivity and an ability of the strain to survive at conditions of nitrogen limitation. Production of Fibrinolytic Enzyme by Streptomyces Rimosus at Conditions of Nitrogen Limitation Victoria Gesheva Stephan Angeloff Institute of Microbiogy, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria Journal of Microbial & Biochemical Technology Open Access JMBT/Vol.1 Issue 1 *Corresponding author: Victoria Gesheva, Stephan Angeloff Institute of Microbiogy, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria Email: [email protected] Received December 08, 2009; Accepted December 24, 2009; Published December 24, 2009 Citation: Gesheva V (2009) Production of Fibrinolytic Enzyme by Streptomyces Rimosus at Conditions of Nitrogen Limitation. J Microb Biochem Technol 1: 057-058. doi:10.4172/1948-5948.1000011 Copyright: © 2009 Gesheva V. This is an open-access article distributed under the terms of the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.